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Wednesday, July 29, 2020 | History

1 edition of Bioassay of dapsone for possible carcinogenicity. found in the catalog.

Bioassay of dapsone for possible carcinogenicity.

Bioassay of dapsone for possible carcinogenicity.

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  • 32 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Program, Carcinogen Bioasay and Program Resources Branch in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Sulfones -- Toxicology.

  • Edition Notes

    SeriesDHEW publication ; no. (NIH) 77-820, Carcinogenesis technical report series ; no. 20, National Cancer Institute carcinogenesis technical report series -- no. 20., DHEW publication -- no. (NIH) 77-820.
    The Physical Object
    Paginationxi, 97 p. :
    Number of Pages97
    ID Numbers
    Open LibraryOL17817381M

    The compounds 4,4′-sulfonyldianiline (dapsone) and 4,4′-thiodianiline (I) were tested for possible carcinogenicity in F rats and B 6 C 3 F 1 mice. Groups of 35 rats and 35 mice of each sex were given either dapsone or compound (I) in the feed. Matched controls consisted of 15 untreated rats and 14 untreated mice of each :// Its carcinogenicity has been studied only with high doses but these produced high levels of induced tumours. Although the available data is limited, the analogy to the structurally similar substances 4,4'-diaminodiphenylmethane and 4,4'-oxydianiline justifies the classification of 4,4'-thiodianiline in Section III A 2) of the MAK

    6. Bioassay of pyrazinamide for possible carcinogenicity. National Cancer Institute Carcinogenesis Technical Report Series No. 48, 7. Zerger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of chemicals. Environ Mutagen. ; 9 (Suppl 9): ://   Dapsone 1 July Dapsone (4,4'-Diaminodiphenyl sulfone; 4,4'-Sulfonyldianiline) Dapsone is a sulfone used in the treatment of leprosy, alone or in combination with other drugs, and also as a primary treatment for Dermatitis herpetiformis. Dapsone has also been used to

    |a Bioassay of sulfisoxazole for possible carcinogenicity |h [electronic resource] / |c Carcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Bioassay of piperonyl butoxide for possible carcinogenicity Published: () Bioassays of DDT, TDE, and p, p'-DDE for possible carcinogenicity Published: () Bioassay of dixathion for possible carcinogenicity Published: ()


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Bioassay of dapsone for possible carcinogenicity Download PDF EPUB FB2

Bioassay of dapsone for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: Marshall Steinberg; National Cancer Institute (U.S.).

Carcinogen Bioassay and Program Resources :// Get this from a library. Bioassay of dapsone for possible carcinogenicity. [Carcinogenesis Program (National Cancer Institute (U.S.)).

Carcinogen Bioassay and Program Resources Branch.;]   A bioassay of dapsone, 4,4'-sulfonyldianiline, for possible carcinogenicity was conducted by administering the test material in Eeed to Fischer rats and B6C3F1 :// Bibliography: p.

A bioassay of dapsone, 4,4'-sulfonyldianiline, for possible carcinogenicity was conducted by administering the test material in feed to Fischer rats and B6C3F1 mice.

Groups of 35 rats and 35 mice of each sex were administered dapsone at one of two doses, either or 1, ppm for rats and either or 1, ppm for :// Carcinogenicity of dapsone in mice and rats Carcinogenicity of dapsone in mice and rats Griciute, Laima; Tomatis, L.

Dapsone (4,4'-diamino-diphenyl sulfone) has been tested for possible carcinogenicity in long-term animal experiments. BDIV rats and C,BL mice received a % aqueous suspension of dapsone by intragastric :// Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V.

() Reproducibility of microbial mutagenicity assays  › Home › Chemical Effects in Biological Systems (CEBS). BIOASSAY OF ANTHRANILIC ACID FOR POSSIBLE CARCINOGENICITY CAS NO. [National Cancer Institute] on *FREE* shipping on qualifying offers. US Department of Health National Cancer Institute Carcinogenesis Technical Report no.

We have been screening commonly used pharmaceuticals for possible carcinogenic effects for over 30 years, identifying drug recipients in an historical database consisting of prescriptions issued at the Kaiser Permanente San Francisco medical center topersons during the years to (2–5).

The minority of the committee believes that the process for selecting doses to be used in a carcinogenicity bioassay should be modified. Specifically, the minority recommends that dose selection be done by a panel of experts on the basis of careful evaluation of appropriate subchronic studies conducted before the bioassay is ://   4,4'-Sulfonyldianiline (Dapsone): Target Organs and Levels of Evidence for TR Bioassay of Dapsone for Possible Carcinogenicity (CASRN ) Chemical (Study Title)   A bioassay of hexachlorophene for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer rats.

Groups of 24 rats of each sex were administered hexachlorophene at one of three doses, eit 50, or ppm, for weeks. Higher doses of ppm, used in 8-week subchronic   Long-Term Carcinogenicity.

2-Year (Dosed-Feed) (C) Completed. TR (NIH Number: ) (Peer Review Approval 07/25/A) Bioassay of Dapsone for Possible Carcinogenicity (CASRN ) Rats: F/N; Mice: B6C3F1; Carcinogenesis Results.

Male Rats Positive ; Female Rats Negative ; Male Mice Negative ; Female Mice Negative Dapsone is a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA :// Conducted for the Carcinogen Bioassay and Program Resources Branch, National Cancer Institute, by Southern Research Institute, Birmingham, Ala.

NLM ID: [Book] Carcinogenesis Program (National Cancer Institute (U.S.)). Carcinogen Bioassay and Program Resources Branch. Bioassay of dimethoate for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: Carcinogenesis Program (National Cancer   Bioassay of Dapsone for Possible Carcinogenicity, US Dept of Health, Education, and Welfare publication National Cancer Institute Carcinogenesis Technical Reports Series, National Cancer Institute Carcinogenesis Technical Reports Series,   A bioassay of 3,3'-iminobispropanol dimethanesulfonate (ester) hydrochloride [IPD] for possible carcinogenicity was conducted by administering the test chemical intraperitoneally to Sprague-Dawley rats and B6C3F1 mice.

The IPD was injected three times per week to groups of 35 animals, using doses of 12, 24, or 48 mg/kg for the rats, and 20 or 40 mg/kg for the ://,3'-iminobispropanol-(ester)-(IPD.

Male rats given five daily doses of 1 to mg/kg body weight of "C-aniline accumulated covalently bound radioactivity m red blood cells and liver m a linear dose-dependent manner (the amount of bound material accumulating m liver was slight) However, accumulation of radioactivity m the spleen was seen only at daily doses greater than 10 mg/kg   A bioassay for possible carcinogenicity of technical-grade hexa­ chloroethane was conducted using Osborne-Mendel rats and B6C3F1 mice.

Hexachloroethane in corn oil was administered by gavage, at either of. The present bioassay used to assess whole-sediment toxicity on benthic diatoms was applied in a ring test in which six laboratories in Spain and Portugal participated (Araújo et al., d).

Data indicated that the whole-sediment assay on C. closterium was considered sufficiently successful for possible use as a standard toxicity test due to National Cancer Institute (U.S.). Carcinogen Bioassay and Program Resources Branch. Bioassay of dimethoate for possible carcinogenicity (OCoLC) Online version: Carcinogenesis Program (National Cancer Institute (U.S.)).

Carcinogen Bioassay and Program Resources Branch. Bioassay of dimethoate for possible ://Online book: Additional Physical Format: Print version: National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Bioassay of diazinon for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, National government publication, Internet resource: Document Type: Internet Resource, Computer File